Projects
Viral triggers of autoimmunity and type 1 diabetes
ENDIA study: environmental determinants of islet autoimmunity (www.endia.org.au)
Cord trial: autologous cord blood for prevention of type 1 diabetes
ADDN: Australasian Diabetes Data Network
Research Interests
Childhood diabetes, including the association between enteroviruses and type 1 diabetes (in collaboration with the Virology Research Group at POWH, headed by Professor Bill Rawlinson) and the epidemiology of childhood diabetes (type 1, type 2, Cystic Fibrosis related diabetes and monogenic diabetes). She is also actively involved in research into diabetes complications (in collaboration with Assoc Prof Kim Donaghue at the Children’s Hospital at Westmead).
Awards
2019 Australian Diabetes Society Jeff Flack Diabetes Data Award
2013 Lifetime Honorary Member, Caring and Living as Neighbours
2008 Asia Pacific Pediatric Endocrine Society Excellence in Teaching Award
1997 Australian Paediatric Endocrine Group Young Investigator’s Award
Selected Publications
Craig ME, Kim KW, Isaacs S, Penno M, Hamilton-Williams E, Couper JJ, Rawlinson WD. Early life factors contributing to type 1 diabetes. Diabetologia 2019 in press
Pham-Short A, Donaghue KC, Ambler G, Briody J, Garnett S, Munns CF, Craig ME. Abnormal cortical and trabecular bone in youth with type 1 diabetes and celiac disease. Diabetes Care Jun 2019 [Epub ahead of print]
Zammit NW, Siggs OM, Gray P, Horikawa K, Langley DB, Walters SN…Craig ME, Benitez-Aguirre PB, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. Denisovan, modern human, and mouse TNFAIP3 1 alleles tune A20 2 phosphorylation and immunity Nature Immunology 2019, in press
Kim KW, Allen DW, Briese T, Couper JJ, Barry SC, Colman PG, Cotterill AM, Davis EA, Giles LC, Harrison LC, Harris M, Haynes A, Horton JL, Isaacs SR, Jain K, Lipkin WI, Morahan G, Morbey C, Pang ICN, Papenfuss AT, Penno MAS, Sinnott RO, Soldatos G, Thomson RL, Vuillermin PJ, Wentworth JM, Wilkins MR, Rawlinson WD, Craig ME; ENDIA Study Group. Distinct Gut Virome Profile of Pregnant Women With Type 1 Diabetes in the ENDIA Study. Open Forum Infect Dis 6(2):ofz025, 2019
Kim KW, Horton H, Pang CNI, Jain K, Leung P, Isaacs P, Bull R, Luciani F, Wilkins M, Catteau J, Lipkin W, Rawlinson W, Briese T, Craig ME. Higher abundance of enterovirus A species in the gut of children with islet autoimmunity. Scientific Reports 9(1):1749, 2019
Ampt A, van Gemert T, Craig ME, Donaghue KC, Lain SB, Nassar N. Using population data to understand the epidemiology and risk factors for diabetic ketoacidosis in Australian children with type 1 diabetes. Pediatric Diabetes 2019, in press
Lalwani A, Warren J, Liuwantara D, Hawthorne WJ, O’Connell PJ, Gonzalez FJ, Stokes RA, Chen J, Laybutt DR, Craig ME, Swarbrick MMKing C, Gunton JE. ? Cell Hypoxia-Inducible Factor-1? Is Required for the Prevention of Type 1 Diabetes. Cell Reports, 27(8):2370-2384.e6, 2019
Harbison JE, Roth-Schulze AJ, Giles LC, Tran CD, Ngui MK, Penno MAS, Thomson RL, Wentworth JM, Colman PG, Craig ME, Morahan G, Papenfuss AT, Barry SC, Harrison LC, Couper JJ. Gut microbiome dysbiosis and increased intestinal permeability in children with islet autoimmunity and type 1 diabetes: a prospective cohort study Pediatric Diabetes 2019 in press
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A. Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia. 62(6):1100-1103, 2019
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A. Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia 62(5):744-753, 2019
Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nat Rev Endocrinol. 15(7):429-435, 2019
Isaacs SR, Kim KW, Cheng JX, Bull RA, Stelzer-Braid S, Luciani F, Rawlinson WD, Craig ME. Amplification and next generation sequencing of near full-length human enteroviruses for identification and characterization from clinical samples. Scientific Reports 8(1):11889, 2018
Allen DW, Kim KW, Rawlinson WD, Craig ME. Maternal virus infections in pregnancy and type 1 diabetes in their offspring: systematic review and meta-analysis of observational studies. Reviews in Medical Virology 28(3):e1974, 2018
Craig ME, Prinz N, Boyle CT, Campbell FM, Jones TW, Hofer SE, Simmons JH, Holman N, Tham E, Fröhlich-Reiterer E, DuBose S, Thornton H, King B, Maahs DM, Holl RW, Warner JT; Australasian Diabetes Data Network (ADDN), the T1D Exchange Clinic Network (T1DX), the National Paediatric Diabetes Audit (NPDA) and the Royal College of Paediatrics and Child Health, and the Prospective Diabetes Follow-up Registry (DPV) initiative. Response to Comment on Craig et al. Prevalence of Celiac Disease in 52,721 Youth With Type 1 Diabetes: International Comparison Across Three Continents. Diabetes Care 40:1034-1040, 2017
Marcovecchio ML, Chiesa ST; Bond S, Daneman D, Dawson S, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil AW, Dalton N, Deanfield J, Dunger DB, on behalf of the Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT) study group. ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes. New England Journal of Medicine. 377(18):1733-1745, 2017
Pham-Short A, Donaghue KC, Ambler G, Garnett S, Craig ME. Greater postprandial glucose excursions and inadequate nutrient intake in youth with type 1 diabetes and celiac disease. Scientific Reports 24;7:45286. doi: 10.1038/srep45286, 2017
Velayutham V, Benitez-Aguirre PZ, Craig ME, Liew G, Wong TY, Jenkins AJ, Donaghue KC. Innovative technology shows impact of glycaemic control on peripheral retinal vessels in adolescents with type 1 diabetes. Diabetologia 60(10):2103-2110, 2017
Isaacs SR, Wang J, Kim KW, Yin C, Zhou L, Mi QS, Craig ME. MicroRNAs in Type 1 Diabetes: Complex Interregulation of the Immune System, ? Cell Function and Viral Infections. Curr Diab Rep. Dec;16(12):133, 2016
Kim KW, Ho A, Alshabee-Akil A, Hardikar AA, Kay TW, Rawlinson WD, Craig ME. Coxsackievirus B5 Infection Induces Dysregulation of MicroRNAs Predicted to Target Known Type 1 Diabetes Risk Genes in Human Pancreatic Islets. Diabetes 65(4):996-1003, 2016
Knip M, Åkerblom HK, Becker D, Dosch HM, Dupre J, Fraser W, Howard N, Ilonen J, Krischer JP, Kordonouri O, Lawson ML, Palmer JP, Savilahti E, Vaarala O, Virtanen SM; TRIGR Study Group. Hydrolyzed infant formula and early ?-cell autoimmunity: a randomized clinical trial. JAMA 11;311(22):2279-87, 2014
Penno MA, Couper JJ, Craig ME, Colman PG, Rawlinson WD, Cotterill AM, Jones TW, Harrison LC. Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatrics, 13(1): 124, 2013
Craig ME, Nair S, Stein H, Rawlinson WD. Viruses and Diabetes: a new look at an old story (Invited review). Pediatric Diabetes, 14, 149-58, 2013
Yeung WC, Al-Shabeeb A, Pang CN, Wilkins MR, Catteau J, Howard NJ, Rawlinson WD, Craig ME. Children with islet autoimmunity and enterovirus infection demonstrate a distinct cytokine profile. Diabetes, 61(6): 1500-8, 2012.
Yeung G, Rawlinson WD, Craig ME. Enterovirus Infection and Type 1 Diabetes Mellitus – A systematic review of molecular studies. British Medical Journal 342:d35 doi:10.1136/bmj.d35 2011
